Molecular assessment of Plasmodium falciparum resistance to antimalarial 3 drugs in Papua New Guinea using an extended ligase detection reaction - 4 fluorescent microsphere assay 5 6
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چکیده
6 Rina P. M. Wong, Harin Karunajeewa, Ivo Mueller, Peter Siba, Peter A. Zimmerman, 7 Timothy M. E. Davis 8 9 1. School of Medicine and Pharmacology, Fremantle Unit, University of Western 10 Australia, Nedlands, Western Australia, Australia. 11 2. Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea. 12 3. The Center for Global Health and Diseases, Case Western Reserve University, 13 Cleveland, Ohio, United States of America. 14 15 Running head: P. falciparum resistance in PNG 16 17 Correspondence and reprints: Professor T. M. E. Davis, University of Western Australia, 18 School of Medicine and Pharmacology, Fremantle Hospital, PO Box 480, Fremantle, 19 Western Australia 6959, Australia. Telephone: +618 9431 3229; Fax: +618 9431 2977; 20 email: [email protected] 21 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00939-10 AAC Accepts, published online ahead of print on 15 November 2010
منابع مشابه
Molecular assessment of Plasmodium falciparum resistance to antimalarial drugs in Papua New Guinea using an extended ligase detection reaction fluorescent microsphere assay.
Surveillance for Plasmodium falciparum drug resistance mutations is becoming an established tool for assessing antimalarial treatment effectiveness. We used an extended version of a high-throughput post-PCR multiplexed ligase detection reaction fluorescent microsphere assay (LDR-FMA) to detect single-nucleotide P. falciparum drug resistance polymorphisms in 402 isolates from children in Papua N...
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